A previously unreported metabolite of high-dose morphine treatment, hydromorphone, has recently been discovered by a select few laboratories. By John Constantine, BS, Andrea Terrell, PhD, Robert Foery, PhD, DABCC/TC and Breain Ma'Ayteh, MA Recently, a toxicologist at our laboratory received a frantic phone call from a patient participating in high-dose morphine therapy. The reason for his call? He’d just been discharged from his pain clinic. The reason for his dismissal?