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Loading metrics Open Access Peer-reviewed Research Article Citation: Smart K, Ure A, Johnsen N, Aflatooni S, Cortes JA, Palma G, et al. (2026) Moderate-to-severe chronic spontaneous urticaria is associated with increased risk of immune-mediated diseases: A population-based study. PLoS One 21(9): e0358883.
1 Introduction Hidradenitis suppurativa (HS) is a chronic, inflammatory skin condition that causes significant morbidity in pediatric patients [1, 2]. HS affects approximately 0.028% of children and adolescents in the United States, with higher prevalence observed in African American girls aged 15–17 years [3]. Moreover, pediatric HS is frequently underdiagnosed, with a median symptom duration of 2.5 years prior to formal HS diagnosis [4].
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