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Articles by Andreas Wack
Never trust a single myeloid marker: Ly6G on repair-promoting lung macrophages
Abstract Short-lived repair-promoting macrophages are recruited to foci of lung damage during influenza infection—and they are Ly6G positive (see related Research Article by Ruscitti et al.). Get full access to this article View all available purchase options and get full access to this article. REFERENCES AND NOTES 1 C. Ruscitti, J. Abinet, P. Maréchal, M. Meunier, C. de Meeûs, D. Vanneste, P. Janssen, M. Dourcy, M. Thiry, F. Bureau, C. Schneider, B. Machiels, A. Hidalgo, F. Ginhoux, B. G. Dewals, J. Guiot, F.
Eating vegetables could help ease lung illness - study
Researchers from the Francis Crick Institute examined a protein called the aryl hydrocarbon receptor (AHR), which can be activated by natural molecules in this type of vegetable. The effect AHR has on immune cells is well understood but now scientists have found that it also plays a role in endothelial cells lining blood vessels in the lung. The lung has a barrier made up of two layers, one of endothelial cells and one of epithelial cells, which allow oxygen to enter.
Host-directed immunotherapy of viral and bacterial infections: past, present and future - Nature Reviews Immunology
Abstract The advent of COVID-19 and the persistent threat of infectious diseases such as tuberculosis, malaria, influenza and HIV/AIDS remind us of the marked impact that infections continue to have on public health. Some of the most effective protective measures are vaccines but these have been difficult to develop for some of these infectious diseases even after decades of research.
Monocyte and dendritic cell defects in COVID-19
Monocytes, plasmacytoid and conventional dendritic cells are crucial for antiviral immune responses. A new study now compares severe and moderate cases of COVID-19 and links defects in viral sensing, interferon and antigen presentation pathways, associated with upregulated apoptosis and inflammatory pathways, to high COVID-19 severity. Recent studies have implicated COVID-19 as an infection with complex response patterns that involve many immune cell types.
Monocytes work harder under pressure
The mechano-sensitive membrane channel PIEZO1 coordinates immune defense in the lungs. Fig. 1: Role of pressure sensing in lung immunity. References 1. Coste, B. et al. Science 330, 55–60 (2010). 2. Murthy, S. E., Dubin, A. E. & Patapoutian, A. Nat. Rev. Mol. Cell Biol. 18, 771–783 (2017). 3. Solis, A. G. et al. Nature 573, Nature 69–74 (2019). 4. Huse, M. Nat. Rev. Immunol. 17, 679–690 (2017). 5. Maruyama, K., Nemoto, E. & Yamada, S. Inflamm. Regen. 39, 3 (2019). 6. Wang, L. et al. Nature 573, 225–229 (2019). 7. Zhao, Q. et al.
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