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WHAT IS THE CURRENT KNOWLEDGE ON THE TOPIC? B- and T-lymphocyte attenuator (BTLA) is an immunoglobulin superfamily member and part of a family of checkpoint inhibitory receptors that negatively regulate immune cell activation. The natural ligand for BTLA is herpes virus entry mediator (HVEM), and binding of HVEM to BTLA leads to attenuation of lymphocyte activation. WHAT QUESTION DID THIS STUDY ADDRESS?
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