Is this you? As a journalist, you can create a free Muck Rack account to customize your profile, list your contact preferences, and upload a portfolio of your best work.
Claim your profile
Articles by Andrew Riselli
Early identification of suboptimal responders to metformin in type 2 diabetes using long-term real-world HbA1c trajectories
The authors have declared no competing interest. I confirm all relevant ethical guidelines have been followed, and any necessary IRB and/or ethics committee approvals have been obtained. Yes The details of the IRB/oversight body that provided approval or exemption for the research described are given below: This study used de-identified electronic health record data provided under an institutional data use agreement.
Identification and Clinical Evaluation of Potential Biomarkers for Breast Cancer Resistance Protein (BCRP/ABCG2)
WHAT IS THE CURRENT KNOWLEDGE ON THE TOPIC? BCRP is a major determinant of exposure and response to various drugs. Although biomarkers have been evaluated for several clinically important transporters, reliable BCRP biomarkers are limited. Riboflavin is a proposed BCRP biomarker; however, its complex pharmacokinetics require further investigation and highlight the need for additional and more robust biomarkers to assess clinical BCRP function. WHAT QUESTION DID THIS STUDY ADDRESS?
Proteomic Profiling Reveals Age-Related Changes in Transporter Proteins in the Human Blood-Brain Barrier
Abstract The Blood-Brain Barrier (BBB) is a crucial, selective barrier that regulates the entry of molecules including nutrients, environmental toxins, and therapeutic medications into the brain. This function relies heavily on brain endothelial cell proteins, particularly transporters and tight junction proteins. The BBB continues to develop postnatally, adapting its selective barrier function across different developmental phases, and alters with aging and disease.
Membrane transporters in drug development and as determinants of precision medicine - Nature Reviews Drug Discovery
Abstract The effect of membrane transporters on drug disposition, efficacy and safety is now well recognized. Since the initial publication from the International Transporter Consortium, significant progress has been made in understanding the roles and functions of transporters, as well as in the development of tools and models to assess and predict transporter-mediated activity, toxicity and drug–drug interactions (DDIs).
Characterization of P‐glycoprotein orthologs from human, sheep, pig, dog, and cat
Abstract The ATP-binding cassette transporter P-glycoprotein (P-gp) limits the oral bioavailability of many drugs. Although P-gp has been well studied in humans and mice, little is known about the substrate specificities of many of its species orthologs. To address this, we performed in vitro analysis of P-gp transporter function using HEK293 cells stably expressing human, ovine, porcine, canine, and feline P-gp.
Show More
loading
Actions
Is this you?
As a journalist, you can create a free Muck Rack account to customize your profile, list your contact preferences, and upload a portfolio of your best work.Get in touch with Andrew
Contact Andrew, search articles and posts on X, monitor coverage, and track replies from one place.
Learn more about Muck Rack