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4. Discussion Historically, GISTs as a separate entity were firstly described by Mazur and Clark in 1983, who distinguished them from gastrointestinal smooth-muscle and nerve sheath tumors [8]. A few years later, in 1998, Kindblom et al. reported that the origin of these tumors arose from pluripotential mesenchymal stem cells which differentiate into the interstitial cell of Cajal [9].
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