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Introduction CDC7 is a serine–threonine kinase that has important roles in both the initiation of DNA replication, where it phosphorylates the MCM2-7 helicase complex to promote origin firing and at replication forks [[1, 2]], where it controls the activity of the MRE11 nuclease and is vital for efficient replication fork restart and modulating fork speed in response to mild topological stress [[3]].
Highlights: • STAT1 and NTD mutants can be stably expressed in U3A cells • Similar effects of wild-type and mutant STAT1 on proliferation ± IFNα • STAT1FA accentuates ɣH2AX accumulation and apoptosis upon ɣ-irradiation Introduction Binding of cytokines and growth hormones to cognate receptors activates the inducible transcription factors STAT1,-2,-3,-4,-5A,-5B,-6.
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