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Articles by Ann Le
A heritability-optimized method for functional prioritization of rare coding variants in complex traits
Abstract Population sequencing studies are uncovering millions of missense rare variants (RVs) implicated in the ‘missing heritability’ of complex diseases, yet distinguishing functional from neutral variation remains challenging. Here we present rare variant heritability-optimized scores (RovHer), a heritability-optimized method for inferring a variant’s probability of being functional (that is, its contribution to trait variance).
Carolina Woman Magazine
“Harumi’s Japanese Cooking” By Harumi Kurihara Published by The Berkeley Publishing Group Pan-Fried Noodles With Pork and Bok Choy 2 inches fresh ginger, peeled 2 to 3 bok choy 4 ounces pork (most cuts will do) Salt and pepper 1-1/2 cups hot water 1 teaspoon Chinese soup paste or a mix of chicken and beef stock 1 tablespoon soy sauce 1 tablespoon shokoshu (Chinese rice wine that has a stronger flavor than sake) 1 teaspoon oyster sauce 2 tablespoons sunflower or vegetable oil 5 to 6 ounces...
Polygenic Risk Scores in Myocardial Injury After Noncardiac Surgery: A VISION Substudy
Introduction Worldwide, 1 in every 30 to 40 adults will undergo a noncardiac surgery annually.1 While noncardiac surgeries can greatly improve a patient’s quality of life, perioperative complications may occur due to the patient's underlying comorbidities (eg, coronary artery disease) and the physiological stress associated with the surgery.
Surrogate Adiposity Markers and Mortality
Key Points Question Among body mass index, fat mass index, and waist-to-hip (WHR) ratio, what is the optimal adiposity measure with the strongest association with mortality outcomes in adults? Findings In this cohort study consisting of 387 672 UK adult participants from the UK Biobank, WHR was found to have the strongest and most consistent association with all-cause and cause-specific mortality.
Frailty among older surgical patients and risk of hospital acquired adverse events: The South‐Western Sydney frailty and nurse sensitive indicators study
Abstract Background While advances in healthcare mean people are living longer, increasing frailty is a potential consequence of this. The relationship between frailty among older surgical patients and hospital acquired adverse events has not been extensively explored. We sought to describe the relationship between increasing frailty among older surgical patients and the risk of hospital acquired adverse events.
Kickstarter >> Creative Minds Journal: An Innovative New Way To Journal! by Ann Le
There’s no reason to sacrifice creativity because you’re too busy. We got that taken care of for you! The Creative Minds Journal comes with a Planning sticker pack for you to create your life in days, weeks and months. All you have to do is peel and stick them to the pages; you control your destiny. Do you like to use paints and markers? We got you covered too! With all the fun markers and paints out there, we pride ourselves in the quality of our 100g paper.
Vogue takes over the YouTube Space NY for Fashion Week
YouTube Space NY is going high fashion, at least for a week. To celebrate New York Fashion Week, Condé Nast will bring brands like Vogue and Teen Vogue to takeover the YouTube Space in Chelsea. It announced the takeover with a video featuring model (and newly minted YouTuber) Karlie Kloss packing up all the essentials from the Vogue offices for the big move, under the direction of icon Anna Wintour.
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