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1 INTRODUCTION Ubiquitin protein ligase E3B (UBE3B) and ubiquitin protein ligase E3C (UBE3C) are closely related homologous to E6AP carboxyl terminus (HECT) E3 ubiquitin ligases that catalyze ubiquitin transfer through a conserved C-terminal HECT domain (Fokkens et al., 2026; Huibregtse et al., 1995; Lorenz, 2018; Rotin & Kumar, 2009; Wang et al., 2020).
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