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Articles by Anna Mosikian
Prediction scale of response to liraglutide therapy as the method for increase of treatment efficacy in type 2 diabetes
In the Russian Federation, the incidence rates of obesity among men and women aged 25–64 years are 26.9 and 30.8%, respectively and the incidence of type 2 diabetes mellitus (T2DM), according to the NATION study, is 5.4% of the population [1]. According to the T2DM registry, as of 1 January 2019, the average incidence is 2885.7 per 100,000 population [2]. Obesity is the leading etiological factor in T2DM pathogenesis.
Efficacy and safety of GP40021 insulin lispro biphasic compared with Humalog Mix 25 in Type 2 diabetes mellitus patients
Journal of Comparative Effectiveness ResearchAhead of Print Research Article , Anna A Mosikian , , , , , , , & Abstract Aim: To compare safety (immunogenicity) and efficacy of a biosimilar insulin GP-Lis25 and a reference insulin Ly-Lis25 (Humalog Mix 25) in Type 2 diabetes mellitus (T2D) patients. Materials & methods: This randomized open-label, 26-week clinical trial enrolled 210 T2D patients, randomized 1:1 to twice-daily GP-Lis25 or Ly-Lis25.
Safety and efficacy of GP40061 compared with originator insulin glargine (Lantus®): a randomized open-label clinical trial
Journal of Comparative Effectiveness ResearchAhead of Print Research Article , Anna A Mosikian *Author for correspondence: E-mail Address: mosikian.anna@gmail.com Clinical Trials Department, OOO GEROPHARM, Saint-Petersburg, Russia , , , , , , , & Abstract Aim: To compare safety (immunogenicity) and efficacy of GP40061 insulin glargine (GP-Gla) and Lantus® (Sanofi glargine, Sa-Gla) in people with diabetes mellitus.
Possible approaches to CYP2C9-guided prescription of sulfonylureas in Russia
Possible approaches to CYP2C9-guided prescription of sulfonylureas in Russia Aim: To evaluate a possible role of CYP2C9 genotyping for sulfonylureas (SUs) prescription in Russia. Materials & methods: We have collected the current data on correlation between SUs pharmacodynamics and CYP2C9 polymorphisms. We have evaluated the frequency of CYP2C9 polymorphisms in Russia by reviewing the literature published from 2004 to 2015 on Russian CYP2C9.
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