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Anna Ponek

As seen in: Nature, ACS Publications, BioRxiv
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Articles by Anna Ponek

SORBS2 regulates diastolic function through cytoskeletal networks and calcium handling

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By Zexuan Wu, Camille E. Blandin, Jiehui Chen, Jiajin Li, Qing Ma, Michael Peters, Anna Ponek, Kevin Parker, Fujian Lu, William Pu, Dogacan Yucel
| Nature Verified
Abstract Diastolic dysfunction, defined by impaired relaxation and increased ventricular stiffness, is central to heart failure with preserved ejection fraction, yet cardiomyocyte-intrinsic mechanisms remain incompletely understood. Here, we show that SORBS2 is a vital component of murine cardiomyocyte adhesion complexes. Its genetic ablation in mice causes progressive diastolic dysfunction with preserved systolic function, accompanied by atrial enlargement and reduced survival.
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Generation of Orthogonal Gradients of the Matrix Stiffness and Chemotactic Cues in a Suspended Array of Hydrogel to Study hMSCs Migration

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By Zhen Xu, Anna Ponek, Jordan Thomas, Yibing Qyang
| ACS Publications
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CHD4 Interacts With TBX5 to Maintain the Gene Regulatory Network of Postnatal Atrial Cardiomyocytes

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By Mason E Sweat, Wei Shi, Erin Keating, Anna Ponek
| BioRxiv
Abstract Atrial fibrillation (AF) is the most common sustained arrhythmia, affecting 59 million individuals worldwide. Impairment of atrial cardiomyocyte (aCM) gene regulatory mechanisms predisposes to atrial fibrillation. The transcription factor TBX5 is essential for normal atrial rhythm, and its inactivation causes loss of aCM enhancer accessibility, looping, and transcriptional identity. Here we investigated the mechanisms by which TBX5 regulates chromatin organization.
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