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Anna Pulimood

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Articles by Anna Pulimood

Pediatric intestinal enteroids derived from very early onset inflammatory bowel disease reveal differences in growth, morphology, and barrier function

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By B. Vijayalekshmi, Amit Dutta, A. Joseph, Ebby George Simon, Sasirekha Ramani, Mary K Estes, Bhuvaneswari Selvam, B. Sandya Rani, Honorine Ward, Anna Pulimood, Sitara S. R. Ajjampur
| Nature Verified
Abstract Pediatric inflammatory bowel disease (IBD) presents more aggressively than adult-onset disease; however, epithelial pathophysiology remains poorly understood due to limited access to patient tissue. Human intestinal enteroids (HIEs) are a powerful model for investigating disease phenotypes and heterogeneity. We characterised duodenal HIEs from two cases with Crohn’s disease (ED-71 and ED-81) and one control with intestinal obstruction (ED-19), all aged <2years.
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