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The immaturity of human induced pluripotent stem cell-derived cardiomyocytes (iPSC-CMs) is a major limitation for their use in drug screening to identify pro-arrhythmogenic or cardiotoxic molecules. Here, we demonstrate an approach that combines lipid-enriched maturation medium with a high concentration of calcium, nanopatterning of culture surfaces and electrostimulation to generate iPSC-CMs with advanced electrophysiological, structural and metabolic phenotypes.
The immature phenotype of human induced pluripotent stem cell-derived cardiomyocytes (iPSC-CMs) represents a major limitation for their application in disease modelling, identification of cardiotoxic or pro-arrhythmic compounds, and for guiding personalized drug selection for patients.
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