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Correspondence Walter Stummer: University Hospital of Münster, Germany. walter.stummer@ukmuenster.de. INCLUDE WHEN CITING Published online April 4, 2025; DOI: 10.3171/2024.12.JNS242790. Disclosures Dr. Suero Molina reported financial research support from Carl Zeiss Meditec outside the submitted work. Dr. Schwake reported grants from Silony Medical and Spineart and nonfinancial support from Stryker outside the submitted work.
Abstract Complete resection of malignant gliomas is hampered by the difficulty in distinguishing tumor cells at the infiltration zone. Fluorescence guidance with 5-ALA assists in reaching this goal. Using hyperspectral imaging, previous work characterized five fluorophores’ emission spectra in most human brain tumors.
Abstract High-grade gliomas (HGG) carry a dismal prognosis. Diagnosis comprises MRI followed by histopathological evaluation of tissue; no blood biomarker is available. Patients are subjected to serial MRIs and, if unclear, surgery for monitoring of tumor recurrence, which is laborious. MRI provides only limited diagnostic information regarding the differentiation of true tumor progression from therapy-associated side effects.
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