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Annet Simons

As seen in: Nature, Genome Medicine
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Articles by Annet Simons

Transcription-based identification of uncharacterized genes in the human immune response

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By Emil Vorsteveld, Simone Kersten, Charlotte Kaffa, Annet Simons, Mihai G. Netea, Alexander Hoischen, Peter A. C. ’t Hoen
| Nature Verified
Abstract Host-pathogen interactions are shaped by the nature of the pathogen and by host-related factors. Human host responses can be characterized in microbe-stimulated immune cells using transcriptomics. We set out to characterize gene expression changes as a result of microbial in vitro stimulation in medium-cultured human primary immune cells, using four pathogen ligands representing bacteria (LPS and S. aureus), viruses (Poly(I:C)) and fungi (C.
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Exome sequencing in routine diagnostics: a generic test for 254 patients with primary immunodeficiencies

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By Peer Arts, Annet Simons, Mofareh S. AlZahrani, Elanur Yilmaz
| Genome Medicine Verified
Peer Arts1, 2, Annet Simons1, Mofareh S. AlZahrani3, Elanur Yilmaz1, 4, Eman AlIdrissi3, Koen J. van Aerde5, Njood Alenezi3, Hamza A. AlGhamdi3, Hadeel A. AlJubab3, Abdulrahman A. Al-Hussaini3, Fahad AlManjomi6, Alaa B. Alsaad3, Badr Alsaleem3, Abdulrahman A. Andijani3, Ali Asery3, Walid Ballourah6, Chantal P. Bleeker-Rovers7, Marcel van Deuren7, Michiel van der Flier5, 8, Erica H. Gerkes9, Christian Gilissen1, Murad K. Habazi3, Jayne Y. Hehir-Kwa1, 10, Stefanie S. Henriet5, Esther P.
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