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Introduction Skin aging is a progressive biological process accompanied by structural and functional changes in the cutaneous microenvironment, including altered sebaceous activity, barrier function, hydration status, immune regulation, and susceptibility to external stressors.1–3 These changes may reshape the ecological conditions that support resident microbial communities.
Back to Journals » Clinical, Cosmetic and Investigational Dermatology » Volume 19 Authors Zhou J , Mehling A, Ye Y, Guo Y, Hu X , Song L Received 22 May 2026 Accepted for publication 23 September 2026 Published 12 October 2026 Volume 2026:19 626939 DOI https://doi.org/10.2147/CCID.S626939 Checked for plagiarism Yes Review by Single anonymous peer review Peer reviewer comments 6 Editor who approved publication: Dr Monica K.
4.2 Future Grouping Approaches Require Key Components Since the very beginning of grouping substances, “what is similarity?” has been a key question. Grouping uses similarity of known properties of substances (“source” criteria) to predict previously unknown properties or toxicities of a substance in question (target). We have reviewed and discussed the similarity of substances in terms of their impact on human health.
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