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Antigoni Morou

As seen in: Nature, EBioMedicine
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Articles by Antigoni Morou

Immune checkpoint expression on HIV-specific CD4+ T cells and response to their blockade are dependent on lineage and function

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By Elsa Brunet-Ratnasingham, Antigoni Morou, Mathieu Dubé
| EBioMedicine Verified
Summary Background Immune checkpoint blockade (ICB) partially reverses the dysfunctional state of antigen-specific T cell in chronic infections. However, its impact on the diverse subsets of CD4+ T cells in humans is largely unknown. Methods We examined immune checkpoint (IC) expression and function in HIV-specific CD4+ T cells of viremic individuals (≥5000 vRNA cp/ml, n = 17) prior to ART and persons with spontaneous (n = 11) or therapy-induced (n = 16) viral suppression (<40 cp/ml).
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Altered differentiation is central to HIV-specific CD4+ T cell dysfunction in progressive disease

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By Nathalie Brassard, Julia Niessl, Daniel Kaufmann, Antigoni Morou
| Nature Verified
Abstract Dysfunction of virus-specific CD4+ T cells in chronic human infections is poorly understood. We performed genome-wide transcriptional analyses and functional assays of CD4+ T cells specific for human immunodeficiency virus (HIV) from HIV-infected people before and after initiation of antiretroviral therapy (ART). A follicular helper T cell (TFH cell)-like profile characterized HIV-specific CD4+ T cells in viremic infection.
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