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Ultrahigh-Mass Resolution Mass Spectrometry Imaging with an Orbitrap Externally Coupled to a High-Performance Data Acquisition System | Analytical Chemistry
Matrix-assisted laser desorption/ionization-mass spectrometry imaging (MALDI-MSI) enables the analysis of a sample’s molecular composition while simultaneously acquiring information on the spatial distribution of the molecules within it. (1) The increasing popularity of MALDI-MSI stems from its versatility to image many different molecular classes, such as lipids, metabolites, pharmaceuticals, peptides, N-glycans, and intact proteins within tissue sections.
Abstract Desorption electrospray ionisation-mass spectrometry imaging (DESI-MSI) is a powerful imaging technique for the analysis of complex surfaces. However, the often highly complex nature of biological samples is particularly challenging for MSI approaches, as options to appropriately address molecular complexity are limited.
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