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Abstract Changes in corneal curvature have been reported with low-concentration atropine eyedrops for myopia treatment and have been suggested to play a role in the refractive changes observed during atropine therapy. A case of keratoconus was identified from the Western Australia atropine for the treatment of myopia (WA-ATOM) cohort. We tested the null hypothesis that 0.01% atropine eyedrops produce no change in corneal parameters or ectasia risk compared to placebo.
Ed: Myopia is considered a public health epidemic in many Southeast Asian countries where its prevalence has increased rapidly to affect nearly 90% of school leavers. In Australia the prevalence is lower with significant differences between Southeast Asians (40%) and Caucasians (20%); and while it is not at epidemic levels the prevalence is increasing. Nearly half of the global population is expected to be myopic by 2050.
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