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Articles by Arianna Menardi
Early functional neuroimaging alterations in pTau217 biomarker-positive older adults
Abstract Introduction: Early identification of individuals with Alzheimer’s Disease (AD) is key to its successful management. In this regard, plasma biomarkers and functional magnetic resonance imaging alterations could represent useful triage tools for preclinical AD cases. Methods: In this study, we analyzed the relationship between neuroimaging, biological and cognitive data from 88 elderly participants recruited from the University Hospital of Padua.
Understanding the Link Between Functional Profiles and Intelligence Through Dimensionality Reduction and Graph Analysis
Functional gradients are a new approach to model connectivity in a neurocognitive space. Position of frontal regions along the transmodal-unimodal gradient is associated with intelligence scores. This suggests a role of frontal regions in coordinating internal schemata in response to external sensory input. 1 Introduction Current neuroscience conceptualizes behavior as the result of the dynamic interaction of distributed communities of cortical regions and subcortical structures.
Understanding the link between functional profiles and intelligence through dimensionality reduction and graph analysis
New Results doi: https://doi.org/10.1101/2023.04.12.536421 Abstract There is a growing interest in neuroscience for how individual-specific structural and functional features of the cortex relate to cognitive traits. This work builds on previous research which, using classical high-dimensional approaches, has proven that the interindividual variability of functional connectivity profiles reflects differences in fluid intelligence.
Maximizing brain networks engagement via individualized connectome-wide target search
To determine the efficacy of different targeting scenarios, we constructed a model to simulate the transition from an initial state to a desired target state following the application of an external input, mimicking a TMS pulse (Fig. 1C).
A novel tDCS sham approach based on model-driven controlled shunting
Highlights • Canonical On/Off solutions for Sham tDCS do not allow proper blinding. • We tested an “Active-Sham” multi-electrode stimulation based on controlled current shunting. • Comparable scalp sensations were reported for Active-Sham and real Multifocal-tDCS. • A significant difference was observed between Bifocal Sham and Active-Sham conditions. • Active-Sham could improve blinding for both research and clinical trials.
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