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1. Background There is a great deal of cross-cultural variation in age of natural menopause (ANM) [1]; and while it is largely governed by genetic factors [2], it is estimated that up to half of the population variance in menopause timing is the result of non-genetic influences [3]. The number of follicles a woman has is established in utero at around five months gestation, and is therefore finite at approximately seven million [4].
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