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Arryn T Blaine

As seen in: Journal of Pharmacology and Experimental Therapeutics
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Articles by Arryn T Blaine

Identification of 1,3,8-Triazaspiro[4.5]Decane-2,4-Dione Derivatives as a Novel δ Opioid Receptor-Selective Agonist Chemotype

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By Yazan J. Meqbil, Jhoan S. Aguilar, Arryn T Blaine, Lan Chen
| Journal of Pharmacology and Experimental Therapeutics
Abstract δ opioid receptors (DORs) hold potential as a target for neurologic and psychiatric disorders, yet no DOR agonist has proven efficacious in critical phase II clinical trials. The exact reasons for the failure to produce quality drug candidates for the DOR are unclear. However, it is known that certain DOR agonists can induce seizures and exhibit tachyphylaxis.
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Identification of 1,3,8-triazaspiro[4.5]decane-2,4-dione Derivatives as a Novel Delta Opioid Receptor-Selective Agonist Chemotype

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By Jhoan S. Aguilar, Lan Chen, Yazan J. Meqbil, Arryn T Blaine
| Journal of Pharmacology and Experimental Therapeutics
Abstract Delta opioid receptors hold potential as a target for neurological and psychiatric disorders, yet no delta opioid receptor agonist has proven efficacious in critical phase II clinical trials. The exact reasons for the failure to produce quality drug candidates for the delta opioid receptor is nuclear. However, it is known that certain delta opioid receptor agonists can induce seizures and exhibit tachyphylaxis.
Open in Who Shared Issue with article?
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