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Abstract Isatuximab–bortezomib–lenalidomide–dexamethasone (Isa-VRd) has emerged as a standard of care for newly diagnosed multiple myeloma transplant-ineligible patients. A subcutaneous (SC) formulation of isatuximab delivered via an on-body injector (OBI) has been developed to facilitate treatment administration. ISASOCUT is a prospective, multicenter, phase 2 study evaluating the efficacy and tolerability of Isa SC-VRd administered via OBI.
1. Introduction Multiple myeloma (MM) is a plasma cell (PC) malignancy characterized by the proliferation of PCs within the bone marrow, usually in association with the production of a monoclonal immunoglobulin (Ig). MM typically occurs among elderly patients. Indeed, the median age at diagnosis is approximately 70 years old, with nearly one-third of patients above 75 years old. The incidence of MM is increasing as the global population is aging.
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