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Articles by Ashwin Patel
Treatment Experience Using a Micro‐Induction Buprenorphine Protocol for Chronic Pain in Pediatric Sickle Cell Disease
BUP buprenorphine CP chronic pain FOA full opioid agonist LTOT long-term opioid therapy MME morphine milligram equivalent OIH opioid-induced hyperalgesia OME oral morphine equivalents QoL quality of life SCD sickle cell disease SNRI serotonin neuro-uptake inhibitor VOE(s) vaso-occlusive episode(s) 1 Background Sickle cell disease (SCD) is an autosomal recessive hemoglobinopathy, characterized by recurrent painful vaso-occlusive episodes (VOEs), anemia, and progressive end-organ damage [1-3].
Base editing HbS to HbG-Makassar improves hemoglobin function supporting its use in sickle cell disease - Nature Communications
Abstract Adenine base editing can convert sickle hemoglobin (HbS, βΕ6V) to G-Makassar hemoglobin (HbG, βE6A), a naturally occurring variant that is clinically asymptomatic. However, the quality and functionality of purified HbG and of mature HbGG and HbGS red blood cells (RBC) has not been assessed. Here, we develop a mouse model to characterize HbG. Purified HbG appears normal and does not polymerize under hypoxia.
Concerns With Statistical Analysis of 2016 CDC Opioid Guideline and Sickle Cell Outcomes
Concerns With Statistical Analysis of 2016 CDC Opioid Guideline and Sickle Cell Outcomes Opioid Prescribing and Outcomes in Patients With Sickle Cell Disease Post–2016 CDC Guideline Hyeun Ah Kang, PhD; Bofei Wang, PhD; Jamie C. Barner, PhD; Kenneth I. Ataga, MD; Robert C. Mignacca, MD; Alicia Chang, MD; Yahan Zhang, MS Concerns With Statistical Analysis of CDC Opioid Guideline and Sickle Cell Outcomes—Reply Hyeun Ah Kang, PhD; Yahan Zhang, MS; Kenneth I.
Colombia: soundscapes of violence for peace
On 1 December 2023, a ritualized reading of Colombia’s Truth Commission Final Report was held in the Chapel at King’s College London, hosted by the Visual Embodied Methodologies (VEM) network at KCL with former commissioner Alejandro Castillejo. The candlelit event, titled ‘On the Verge of Silence: Sonic and Poetic Fragments’, blended soundscapes and testimonies to create an immersive atmosphere and disposition to listening in the beautiful Chapel at King’s Strand campus.
Diabetes Care for U.S. Immigrants: Why Housing Stability and Food Access Must Come First
WRITTEN BY: Ginger Vieira You only have 15 to 30 minutes to discuss your diabetes health during a typical appointment with your doctor. If you’re also an immigrant who speaks English as a second language or speaks no English at all, those 15 minutes could easily be used up with the usual conversation checklist about your prescriptions, getting enough exercise, and eating more whole foods.
A Studio Life by Grid London on The Bazaar
You can pay securely with A series of illustrations outlining the typical life of the design studio, from essential tools and must haves, to thoughts, visionaries and revelations. Printed in Saphira Posidry Black lithographically on GF Smith Colourplan Vellum white 135gsm. Size A2 (594 x 420mm) rolled and wrapped with care in 100% acid free white tissue paper. Shipped worldwide. Estimated arrival: 21 Dec - 30 Dec* if you buy today *Items may reach before or after the estimated dates.
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