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Introduction Stroke remains a serious global health problem (1–3) and is estimated to affect more than 101 million people worldwide (4). Although stroke mortality has decreased over the past two decades (5), the number of patients with stroke has been steadily increasing, resulting in an increased economic burden due to the rising need for stroke after-care (6). Diabetes mellitus (DM) is considered a prognostic factor as well as the risk factor for stroke.
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In Reply Dr Long and colleagues point out that the SHINE trial1 may have shown additional useful results if patients were stratified based on prestroke glycemic control. Although the sample of patients without diabetes was small, eFigure 1 in Supplement 3 in the article showed that there was no significant difference in the primary outcome by treatment group in the subgroups of patients with or without diabetes.
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