Abstract The necessity for reliable healthcare monitoring following the COVID-19 pandemic has highlighted the limitations of RF-based devices in medical settings. Visible light communication (VLC), which provides inherent security and is resistant to RF interference, is a good alternative. This work proposes a VLC system using DC-biased optical (DCO) orthogonal frequency division multiplexing (OFDM) for resilient, high-speed biomedical data transmission through indoor optical fading channel.