This case report presents a 23-year-old Congolese female patient with HIV on first line antiretroviral drugs (tenofovir–lamivudine–dolutegravir) since November 2019 following HIV diagnosis in a tertiary center. Underlying conditions included tuberculosis (TB) meningitis, which was under treatment since February 2021. The patient trajectory is outlined in Fig. 1. Patient timeline prior to hospitalization in November 2021 The patient history revealed that initial symptoms were dominated by headaches.