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Background Pancreatic cancer has a very poor prognosis as most patients are diagnosed at an advanced stage when curative treatments are not possible. Breath volatile organic compounds (VOCs) have shown potential as novel biomarkers to detect cancer. The aim of the study was to quantify differences in exhaled breath VOCs of patients with pancreatic cancers compared with cohorts without cancer. Methods Patients were recruited to an initial development cohort and a second validation cohort.
Background Pancreatic cancer has a very poor prognosis as most patients are diagnosed at an advanced stage when curative treatments are not possible. Breath volatile organic compounds (VOCs) have shown potential as novel biomarkers to detect cancer. The aim of the study was to quantify differences in exhaled breath VOCs of patients with pancreatic cancers compared with cohorts without cancer. Methods Patients were recruited to an initial development cohort and a second validation cohort.
The role of volatile organic compounds (VOCs) in exhaled breath as biomarkers has been investigated in cancers of the breast, oesophagus, stomach, colon, rectum and lung 9 - 14 . The authors 15 , 16 have previously developed and validated a breath test for the diagnosis of oesophagogastric and colorectal adenocarcinomas.
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