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A 9-year-old British Short Hair cat presented with a 12-month history of progressive exophthalmos to the right eye. A computed tomography (CT) scan was performed, and it revealed a large 3.1 × 2 × 2.3 cm peripherally contrast-enhancing right retrobulbar mass in the region of the zygomatic salivary gland. Preliminary results of a fine-needle aspirate (FNA) were inconclusive, so the mass was surgically excised via the right partial zygomatic ostectomy approach.
The genetic heterogeneity of T-ALL has precluded the use of genetic alterations for risk-based stratification. We reasoned that these diverse genetic lesions might converge on a more limited set of biochemical abnormalities that could be used to identify subsets of T-ALLs that share common mechanisms of chemotherapy resistance. We tested this hypothesis by assessing drug responses in vitro using phosphoflow cytometry in primary T-ALL cells.
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As a journalist, you can create a free Muck Rack account to customize your profile, list your contact preferences, and upload a portfolio of your best work.
