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Supramolecular attack particles Cytotoxic T cells (CTLs) are at the front lines against cancer and chronic infection. T cells kill by secreting caspase-activating granzymes and the pore-forming protein perforin from dense core granules. However, the structural basis of lethal hit delivery has remained unknown. Balint et al. enriched the synaptic output of CTLs to investigate the released form of perforin and granzyme B.
Report View ORCID ProfileŠ. Bálint1, View ORCID ProfileS. Müller2, View ORCID ProfileR. Fischer3, View ORCID ProfileB. M. Kessler3, View ORCID ProfileM. Harkiolaki4, View ORCID ProfileS. Valitutti2,5, View ORCID ProfileM. L. Dustin1,* 1Kennedy Institute of Rheumatology, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, UK. 2Cancer Research Center of Toulouse, INSERM, Toulouse, France.
Debridement and implant retention in the management of hip periprosthetic joint infection P. Sendi, P. O. Lötscher, B. Kessler, P. Graber, W. Zimmerli, M. Clauss Bone Joint J Mar 2017, 99-B (3) 330-336; DOI: 10.1302/0301-620X.99B3.BJJ-2016-0609.R1
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