Aspiration thrombectomy is a feasible alternative to thrombolytics for the treatment of acute pulmonary embolism (PE). The objective of the STRIKE-PE study is to evaluate real-world functional outcomes, safety, and performance of computer-aided mechanical aspiration thrombectomy with the Indigo Aspiration System (Penumbra, Inc., Alameda, CA) for the treatment of PE. The objective of the current abstract is to report results from an interim analysis of this study.