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B. Towler

As seen in: Nature
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Articles by B. Towler

RUNX1 aberrations in blast-phase chronic myeloid leukaemia induce the RNA-binding protein SPATS2L, which promotes growth, survival and stress granule assembly

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By A. Muir, R. Craig, O. Sevim, A. K. Kakkar, M. D. Wilson, G. Horne, M. Copland, S. Mustjoki, S. Jain, H. Webb, T. Chevassut, S. G. Kellaway, B. Towler, RG Morgan, D. A. Palmer, D. Ogilvie-Park, L. Stott, PA Lewis, K. Heesom, S. Adnan-Awad, K. Porkka, N. Bayat, D. Famili, M. J. West, F. K. Mardakheh, A. Tonks
| Nature Verified
Abstract RUNX1 is a critical regulator of hematopoiesis. In CML, somatic RUNX1 mutations and RUNX1::MECOM/EVI1, are associated with TKI resistance and progression to BP-CML. To examine post-transcriptional dysregulation downstream of RUNX1 aberrations, we used orthogonal organic phase separation to characterise the RNA-binding proteome of RUNX1 deficient BP-CML cells.
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β-Catenin interacts with canonical RBPs including MSI2 to associate with a Wnt signalling mRNA network in myeloid leukaemia cells - Oncogene

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By M. Fernanda Wagstaff, A. Goff, H. Park, E. Mancini, A. Blair, O. Sevim, T. Chevassut, L. Castellano, S. Newbury, B. Towler
| Nature Verified
Abstract Wnt/β-catenin signalling is important for normal hematopoietic stem/progenitor cell (HSPC) biology and heavily implicated in acute and chronic myeloid leukaemia (AML and CML). The central mediator β-catenin is an attractive therapeutic target in myeloid neoplasms however its targeting has been hampered by a poor characterisation of its molecular interactions in haematopoietic cells, which will differ from its network in solid tissues.
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