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A patient with castration-resistant prostate cancer (CRPC) was referred to our clinic seeking palliative management of a painful metastasis in the left pelvis. At the time of referral, the patient was receiving [177Lu]Lu-PSMA 617 (Pluvicto®) therapy at an outside institution, with the next scheduled administration approaching within days.
Extravasation of radiopharmaceuticals raises potential concerns, including adverse tissue reactions and reduction in both quantitative accuracy and therapeutic efficacy. This study presents a single-center experience reviewing extravasation events during [177Lu]Lu-DOTATATE administration in peptide receptor radionuclide therapy, assessing their frequency, impact on patient care, and dosimetric effects.
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