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Abstract: Objective To investigate whether a stable and reliable hyperuricemia model can be established in mice with an ICR background via a triple-modeling method ( combined potassium oxazine, hypoxanthine, and 30% yeast paste), and to evaluate the effect of the positive drug febuxostat on the model. Methods A hyperuricemia model of ICR mice was established using a single drug or double- or triple-drug combinations.
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