CONFLICT OF INTEREST STATEMENT The authors have declared no conflicts of interest. REFERENCES 1, . Management of rheumatoid arthritis: an overview. Cell. 2021; 10: 2857. 2, , , et al. Seronegative autoimmune diseases: a challenging diagnosis. Autoimmun Rev. 2022; 21:103143. 3, , . Autoantibodies in rheumatoid arthritis: historical background and novel findings. Clin Rev Allergy Immunol. 2022; 63: 138-151. 4, , , et al. Novel autoantibodies identified in ACPA-negative rheumatoid arthritis. Ann Rheum Dis.