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Abstract Background: The clinical efficacy of PD-1/PD-L1 inhibitors combined with chemotherapy (± targeted agents) in patients with proficient mismatch repair (pMMR) metastatic colorectal cancer (mCRC) remains unclear. This study systematically evaluated the efficacy of this regimen. Methods: We searched PubMed, Web of Science, Embase, the Cochrane Library, and ClinicalTrials.gov for relevant randomized controlled trials (RCTs) published up to May 2026.
AFT Aflatoxin AM Acrylamide BRCA Breast cancer COAD Colorectal cancer EPA Environmental Protection Agency Gly Glyphosate GO Gene ontology GSEA Gene set enrichment analysis KEGG Kyoto Encyclopedia of Genes and Genomes MCC Maximal clustering coefficient MCODE Molecular complex detection MeHg Methylmercury NIEHS National Institute of Environmental Health Sciences NIT Nitrosamines PA Pyrrolizidine alkaloids PBDEs Pentabromodiphenyl ethers PCDDs Dioxins PFOS Perfluorooctane sulfonate PPI...
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