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Abstract Numerous E3 ubiquitin ligases regulate plant immunity through mediating protein homeostasis, yet how homeostasis of E3 ligases is finely regulated per se remains poorly understood. Here, we reveal that the ubiquitin E3 ligase plant U-box 2 (OsPUB2) specifically interacts with OsPUB12 and targets it for ubiquitin-mediated degradation.
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