Is this you? As a journalist, you can create a free Muck Rack account to customize your profile, list your contact preferences, and upload a portfolio of your best work.
Claim your profile
Articles by Baoli Ding
Bioorthogonal Vitamin C Probes Enable Cellular Profiling and Investigation of Lysine Vitcylation
1 Introduction Metabolites are increasingly recognized as active chemical signals that regulate protein function through covalent post-translational modifications (PTMs) [1, 2]. Lysine acylations derived from metabolic intermediates [3], such as acetylation [4, 5], aminoacylation [6], succinylation [7], lactylation [8-10], and pyruvylation [11] have emerged as key mechanisms linking metabolic state to chromatin regulation, transcription, and cellular signaling.
Bioorthogonal Vitamin C Probes Enable Cellular Profiling and Investigation of Lysine Vitcylation
1 Introduction Metabolites are increasingly recognized as active chemical signals that regulate protein function through covalent post-translational modifications (PTMs) [1, 2]. Lysine acylations derived from metabolic intermediates [3], such as acetylation [4, 5], aminoacylation [6], succinylation [7], lactylation [8-10], and pyruvylation [11] have emerged as key mechanisms linking metabolic state to chromatin regulation, transcription, and cellular signaling.
Accelerating the Discovery of Targeted Protein Degraders: Advances in Synthetic Methodologies and Screening Tactics
1 Introduction Targeted protein degradation (TPD) is transforming the landscape of drug discovery by offering new opportunities to pursue targets previously considered “undruggable” [1-4]. Unlike traditional inhibitors that rely on high-affinity occupancy of proteins’ active sites, degraders operate by harnessing the cell's innate ubiquitin-proteasome system (UPS) and the lysosomal pathways to eliminate specific disease-causing proteins via an event-driven mechanism (Figure 1A) [5].
Phenotypic Screening for Targeted Protein Degradation: Strategies, Challenges, and Emerging Opportunities
Abstract Click to copy section linkSection link copied! Phenotypic screening is undergoing a resurgence in the field of targeted protein degradation as a powerful complement to target-based approaches, which are often constrained by requirements for detailed structural and ligand-binding information. Phenotypic protein degrader discovery (PPDD) instead follows a “biology-first” philosophy, identifying active degraders based on cellular responses.
Solid‐Phase Parallel Synthesis of Photo‐cleavable Bifunctional Molecules Enables Efficient Phenotypic Protein Degrader Discovery
Supporting Information As a service to our authors and readers, this journal provides supporting information supplied by the authors. Such materials are peer reviewed and may be re-organized for online delivery, but are not copy-edited or typeset. Technical support issues arising from supporting information (other than missing files) should be addressed to the authors.
PROTAC‐Mediated HDAC7 Protein Degradation Unveils Its Deacetylase‐Independent Proinflammatory Function in Macrophages
1 Introduction Cytokines are essential chemical messengers secreted by immune cells that orchestrate normal immune responses. By interacting with their cellular receptors, cytokines activate downstream signaling cascades, triggering immune reactions that protect the body from inflammation or infection.[1] Therefore, maintaining a dynamic balance of proinflammatory and anti-inflammatory cytokines is crucial for immune homeostasis.
Show More
loading
Actions
Is this you?
As a journalist, you can create a free Muck Rack account to customize your profile, list your contact preferences, and upload a portfolio of your best work.Get in touch with Baoli
Contact Baoli, search articles and posts on X, monitor coverage, and track replies from one place.
Learn more about Muck Rack