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Bei Nan

As seen in: BioRxiv
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Articles by Bei Nan

Structural basis of DNA N6-adenine methylation in eukaryotes

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By Bei Nan, Wentao Yang, Dantong Wang, Lanheng Nie
| BioRxiv
Abstract N6-adenine methylation occurs in both DNA and RNA (referred to as 6mA and m6A, respectively). As an extensively characterized epi-transcriptomic mark found in virtually all eukaryotes, m6A in mRNA is deposited by METTL3-METTL14 complex. As a transcription-associated epigenetic mark abundantly present in many unicellular eukaryotes, 6mA is coordinately maintained by two AMT1 complexes, distinguished by their mutually exclusive subunits, AMT6 and AMT7.
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Dual modes of DNA N6-methyladenine maintenance by distinct methyltransferase complexes

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By Yuanyuan Wang, Zhe Zhang, Wentao Yang, Bei Nan
| BioRxiv
Abstract Stable inheritance of DNA N6-methyladenine (6mA) is crucial for its biological functions in eukaryotes. Here, we identify two distinct methyltransferase (MTase) complexes, both sharing the catalytic subunit AMT1, but featuring AMT6 and AMT7 as their unique components, respectively. While the two complexes are jointly responsible for 6mA maintenance methylation, they exhibit distinct enzymology, DNA/chromatin affinity, genomic distribution, and knockout phenotypes.
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