The authors have declared no competing interest. I confirm all relevant ethical guidelines have been followed, and any necessary IRB and/or ethics committee approvals have been obtained. Yes The details of the IRB/oversight body that provided approval or exemption for the research described are given below: Ethical approval for the UK Biobank was granted by the North West - Haydock Research Ethics Committee (reference no. 21/NW/0157), and all participants provided written informed consent.