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Abstract After spinal cord injury, clinical management aims to support tissue perfusion, but current methods rely on the indirect control of arterial blood pressure without direct measurement of the local blood flow. This limits the ability to tailor drug delivery to the injured tissue. Here, we show that spinal cord blood flow can be regulated using a closed-loop controller that adjusts vasopressor infusion on the basis of real-time ultrasound flow measurement.
Animals All procedures followed NIH guidelines (NIH Publications No. 8023, revised 1978) with approval from the Johns Hopkins Animal Care and Use Committee (protocols RA23M263 and SW23M249). Female Sprague–Dawley rats (275–300 g, Charles River Laboratories) and female Yorkshire pigs (25–30 kg, Oak Hill Genetics) were used. Female animals were chosen to facilitate bladder expression in our chronic injury models.
1 Introduction Brain disorders, particularly aggressive malignancies such as Glioblastoma (GBM), present formidable treatment challenges due to the blood-brain barrier (BBB), characterized by tight junctions between endothelial cells, which restrict the delivery of most therapeutic agents to the brain [1].
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