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Michael RybakMichael Rybak, Pharm.D., M.P.H. is Professor of Pharmacy and Medicine, and Director, Anti-Infective Research Laboratory, Eugene Applebaum College of Pharmacy and Health Science, Wayne State University (WSU), Detroit, MI. BenLomaestro, Pharm.D., is Senior Clinical Pharmacy Specialist in Infectious Diseases, Albany Medical Center, Albany, NY. John C.
Vancomycin was initially dubbed “Mississippi mud” because of the brown color of early formulations, which were about 70% pure. The impurities are thought to have contributed to the incidence of adverse reactions.7,75,76 In the 1960s, purity increased to 75% and in 1985 to 92–95% for Eli Lilly’s vancomycin product.74 Concurrently, a decrease in the reporting of serious adverse events occurred.
Vancomycin was initially dubbed “Mississippi mud” because of the brown color of early formulations, which were about 70% pure. The impurities are thought to have contributed to the incidence of adverse reactions.7,75,76 In the 1960s, purity increased to 75% and in 1985 to 92–95% for Eli Lilly’s vancomycin product.74 Concurrently, a decrease in the reporting of serious adverse events occurred.
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