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Articles by Ben Wesley
Author Correction: Disentangling oncogenic amplicons in esophageal adenocarcinoma - Nature Communications
Correction to: Nature Communications https://doi.org/10.1038/s41467-024-47619-4, published online 14 May 2024 In this article, the affiliation details for Karol Nowicki-Osuch were incorrectly given as ‘Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore, Singapore’ but should have been ‘Irving institute for Cancer Dynamics, Columbia University, New York, USA’. The original article has been corrected.
Disentangling oncogenic amplicons in esophageal adenocarcinoma - Nature Communications
Abstract Esophageal adenocarcinoma is a prominent example of cancer characterized by frequent amplifications in oncogenes. However, the mechanisms leading to amplicons that involve breakage-fusion-bridge cycles and extrachromosomal DNA are poorly understood. Here, we use 710 esophageal adenocarcinoma cases with matched samples and patient-derived organoids to disentangle complex amplicons and their associated mechanisms.
CRISPRmap: Sequencing-free optical pooled screens mapping multi-omic phenotypes in cells and tissue
Abstract Pooled genetic screens are powerful tools to study gene function in a high-throughput manner. Typically, sequencing-based screens require cell lysis, which limits the examination of critical phenotypes such as cell morphology, protein subcellular localization, and cell-cell/tissue interactions. In contrast, emerging optical pooled screening methods enable the investigation of these spatial phenotypes in response to targeted CRISPR perturbations.
Dodgers Win First World Series Since 1988, Join Lakers as LA's 2020 Champs
It was the bottom of the 6th inning in the 2020 World Series. The Dodgers were looking to close out a championship as it was Game 6 and they were up in the series 3-2 against the Tampa Bay Rays. The Rays were leading 1-0 against LA, and Tampa’s starting pitcher, Blake Snell, was pitching as great of a game as oneany could ask for; up until this point, Snell had only allowed for one hit, with nine strikeouts and no runs scored against him.
LeBron James, Anthony Davis lead Lakers to their 17th NBA Championship
LeBron James promised the basketball world that he would continue Kobe Bryant’s legacy nearly nine months ago in response to the shocking news that Bryant had passed away in a horrific helicopter crash. Just a day before the crash, Bryant had tweeted out to James congratulating him on becoming the number three all-time top career scorer, passing Bryant himself.
MLB Extends Playoffs, Is This The Right Year To Do It?
Major League Baseball announced it would be extending its 2020 postseason back in late July. This announcement followed their decision to shorten the regular season from 162 games to a mere 60 in efforts to minimize audience and player exposure to COVID-19. The decision comes as the first time the MLB playoffs have been changed since the introduction of the wild card round back in 2012.
Will Reduced Stadium Capacities Have An Effect On NFL Team Performances?
As professional sports adjust to COVID-19 restrictions, teams around the country are working to make the game-day experience just as exhilarating as it used to be. Much of the excitement stems from every NFL team’s heart and soul: the fans. Previously, stands were packed every Sunday as fans gathered to cheer on their respective teams.
Six Interesting Cars at the 2017 Atlanta Concours d’Elegance | Automobile Magazine
While scale of the Atlanta Concours d’Elegance is nowhere near that of Pebble Beach or Amelia Island, don’t take that as a condemnation of the show as a whole. In fact, the event is just small enough to maintain a relaxed atmosphere while being still significant enough to attract some really impressive vehicle collections. This year’s event was more than double the size of last years and there were plenty of impeccably maintained vehicles from almost every era.
2017 Watkins Glen Vintage Grand Prix | Automobile Magazine
WATKINS GLEN, New York — Vintage racing is a fundamentally sound idea. If seeing classic cars brings a smile to people’s faces, then watching classic cars race is guaranteed to bring grins. What’s not to love about watching a herd of 1960s Minis desperately retain every iota of speed through an uphill corner? That’s the premise behind the Watkins Glen Vintage Grand Prix.
367 Laps of the 2017 24 Hours of Le Mans | Automobile Magazine
I’m going to start off with an obvious truth: everything about The 24 Hours of Le Mans is intense – from the 3PM thundering explosion of sound, to the Porsche Camp’s celebration while the Toyota’s dreams literally burn in front of them, to the end-of-race nerves as a lone, damaged C7.R Corvette fends off two predatory Astons. However, the race is 24 hours long, so interspersed between these bouts of adrenaline and excitement are long stretches of bizarre normality.
Spectator Musings from the 2017 Formula E Berlin ePrix | Automobile Magazine
On the second weekend of June, Templehof, Berlin’s historical WWII era airport, hosted the 2017 Berlin ePrix, a double header in the Formula E championship. For those not familiar, Formula E theoretically offers the cutting-edge technology and intense competition of Formula 1, but with electric cars. In execution, it tries, but the technology is still nascent.
2017 Kustom Kulture Forever: Old School American Steel in Deutschland | Automobile Magazine
For most, Germany is usually associated with high-performance luxury cars, precision engineering, and its famous autobahns. However, every May for the past 4 years, a bunch of people have gathered in Western Germany for a very un-German celebration of hot rods, muscle cars, and Americana. The name of the event, Kustom Kulture Forever, explains it all. The cars ranged from rat-rodded Ford Model Bs to street rod Chevy Bel Airs and even included German Beetles and Kombi busses.
Celebrating Speed, South African-Style, at the 2017 Jaguar Simola HillClimb | Automobile Magazine
KNYASA, South Africa — Roughly halfway between the cities of Cape Town and Port Elizabeth and not far from where the Atlantic Ocean becomes the Indian one sits an estate that plays host every early May to the unique annual celebration of cars and motorsport that is the Jaguar Simola Hillclimb. Started eight years ago by an experienced motorsports coordinator and a former rally driver, the Simola Hillclimb’s current format is similar to that of the famous Goodwood Festival of Speed.
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