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Abstract Group 2 innate lymphoid cells (ILC2) are the sentinels that ensure tissue homeostasis and engage in the immune response to helminths by secreting type 2 cytokines. Here we show that IκBζ, an atypical member of the IκB family, controls basal IL-5 production by ILC2s and governs their effector program during helminth infection and asthma.
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