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Abstract Here we present DynaVelo, a generative neural ordinary differential equation model that learns the joint dynamics of gene expression and transcription factor (TF) motif activity from single-cell multiome data. DynaVelo learns a functional form of the vector field, such that the model can be perturbed in silico and not only used to draw trajectories.
We appreciate the insights provided by Melk et al. in their Comment1 in Nature Medicine. The authors effectively highlight the importance of structured programs in preparing clinician scientists to bridge the gap between clinical practice and research. However, we would like to emphasize the critical role of medical students in this ecosystem and the need for greater accessibility and support at the undergraduate level. We agree with Melk et al.
The need for young health activists was emphasised in a recent Editorial. 1 The Lancet The emerging voices of youth activists. Lancet. 2019; 3931774 Although they might not be as prominent as Greta Thunberg or Malala Yousafzai, plenty of young people are already dedicating themselves to advocate for better health and health care.One association for young people is the European Medical Students' Association (EMSA), which represents medical students from more than 110 medical faculties across Europe.
In his In Focus piece in The Lancet Diabetes & Endocrinology,1x1Morgan, J. Self-determining legal gender: transgender right, or wrong?. Lancet Diabetes Endocrinol. ; 4: 207–208 Summary | Full Text | Full Text PDF | Scopus (1)See all References1 Jules Morgan discusses the change of law regarding self-determination of legal gender in Ireland and explores the topic in a global context.
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