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Abstract Homozygous carriers of the CNDP1 (CTG)5 allele with diabetes mellitus are believed to have a lower risk of developing diabetic kidney disease compared to individuals carrying alleles with higher numbers of this CTG repeat. However, recent studies claimed that homozygosity for the (CTG)5 allele increases the risk of disease progression towards end-stage renal disease and even cardiovascular mortality, at least in women.
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Abstract In diabetic nephropathy (DN), glomerular endothelial cells (GECs) and podocytes undergo pathological alterations, which are influenced by metabolic changes characteristic of diabetes, including hyperglycaemia (HG) and elevated methylglyoxal (MGO) levels. However, it remains insufficiently understood what effects these metabolic factors have on GEC and podocytes and to what extent the interactions between the two cell types can modulate these effects.
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