New Results Jorge Luis-Islas, Monica Luna, Benjamin Floran, View ORCID ProfileRanier Gutierrez doi: https://doi.org/10.1101/2021.04.22.440969 Abstract How do animals experience brain manipulations? Optogenetics has allowed us to manipulate selectively and interrogate neural circuits underlying brain function in health and disease. However, in addition to their evoked physiological functions, it is currently unknown whether mice could perceive arbitrary optogenetic stimulations.