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Articles by Benjamin Franklin Voight
Obesity and adiposity have opposing genetic impacts on human blood traits
Abstract Obesity, hyperlipidemia, and truncal adiposity concordantly elevate cardiovascular disease risks, but have unknown genetic effects on blood trait variation. Using Mendelian randomization, we define unexpectedly opposing roles for generalized obesity and truncal adiposity on blood traits. Elevated genetically determined body mass index (BMI) and lipid levels decreased hemoglobin and hematocrit levels, explaining consistent with clinical observations associating obesity and anemia.
Identifying non-identical-by-descent rare variants in population-scale whole genome sequencing data
Abstract The site frequency spectrum in human populations is not accurately modeled by an infinite sites model, which assumes that all mutations are unique. Despite the pervasiveness of recurrent mutations, we lack computational methods to identify these events at specific sites in population sequencing data. Rare alleles that are identical-by-descent (IBD) are expected to segregate on a long, shared haplotype background that descends from a common ancestor.
Detecting Long-term Balancing Selection using Allele Frequency Correlation
Detecting Long-term Balancing Selection using Allele Frequency Correlation Katherine M Siewert, Benjamin Franklin Voight bioRxiv 112870; doi: https://doi.org/10.1101/112870
Patterns of shared signatures of recent positive selection across human populations
AbstractScans for positive selection in human populations have identified hundreds of sites across the genome with evidence of recent adaptation. These signatures often overlap across populations, but the question of how often these overlaps represent a single ancestral event remains unresolved.
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