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Articles by Benjamin Straube
Multimodal Machine Learning–Based Prediction of Relapse in Major Depressive Disorder
Key Points Question Does machine learning–based integration of multiple data modalities, relative to single data modalities, improve relapse prediction in major depressive disorder? Findings In this prognostic study, depressive relapse within 2 years was predicted among 564 patients with major depressive disorder, with a highest classification accuracy of 64.43%.
Resilience beyond diagnosis: prospective neural correlates of better-than-expected outcomes in depression
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Abstract Resilience, the ability to adapt positively in the face of adversity, is shaped by combined influences of risk and protective factors. Previous neuroimaging studies on resilience have predominantly focused on single factors, often operationalizing resilience dichotomously as the absence of psychiatric disorders despite adversity.
By Vincent Hammes, Katharina Brosch, Paula Usemann, Friederike David, Hannah Scherer, Christina V Schmitter, Jochen Bauer, Tiana Borgers, Kira Flinkenflügel, Dominik Grotegerd, Elisabeth Leehr, Susanne Meinert, Frederike Stein, Lea Teutenberg, Florian Thomas-Odenthal, Udo Dannlowski, Tim Hahn Verified, Hamidreza Jamalabadi, Andreas Jansen, Robert Miller, Igor Nenadic, Benjamin Straube, Albrecht Stroh, Tilo Kircher, Nina Alexander
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Nature
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The effect of SSRI/SNRI antidepressant treatment on the gut microbiota of patients with major depressive disorder
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Abstract The gut microbiome has been linked to major depressive disorder (MDD), yet it remains unclear whether antidepressant treatment influences these associations. This study aimed to clarify the role of serotonin reuptake inhibitors (SSRI/SNRI) in shaping gut microbiome changes observed in MDD.
By Danique Mulder, Leon Fehse, Nils Winter, Lukas Fisch, Marius Welzel, Corinna Bang, Susanne Meinert, Kira Flinkenflügel, Tiana Borgers, Janik Goltermann, Elisabeth Leehr, Carsten Culmsee, Frederike Stein, Florian Thomas-Odenthal, Paula Usemann, Lea Teutenberg, Igor Nenadic, Benjamin Straube, Nina Alexander, Hamidreza Jamalabadi, Andreas Jansen, Robert Nitsch, Andre Franke, Udo Dannlowski, Tilo Kircher, Dominik Heider, Tim Hahn Verified, Janna N. Vrijsen, Philip van Eijndhoven, Indira Tendolkar, Andreas Reif, Sharmili Edwin Thanarajah, Silke Matura, Alejandro Arias Vasquez, Mirjam Bloemendaal, Eugenia Emile Natasha, Andreas Lügering
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Nature
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Disrupted neural response timing and duration during hand movement preparation in schizophrenia spectrum disorder: An fMRI study
Abstract Schizophrenia spectrum disorders (SSD) feature deficits in movement intention, predictive mechanisms, and agency. While prior work characterised BOLD amplitude during movement preparation and temporal dynamics across the entire movement period, it remains unknown whether preparatory neural (BOLD) response timing and duration are selectively impaired in SSD.
Cortical morphometry might predict currently prescribed vs. discontinued medications in bipolar disorder, even after controlling for the cumulative dose effects: An ENIGMA mega-analysis
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Abstract Recent research suggests that brain anatomy may help identify the most effective pharmacological treatment for each individual with bipolar disorder and reduce trial-and-error prescribing. We aimed to investigate whether brain anatomy predicts whether a medication is currently prescribed or has been discontinued, as a proxy for treatment effectiveness.
By Lydia Fortea, Miguel Ángel Rivas-Fernández, Aleix Solanes, Sinead King, Leila Nabulsi, Martin Alda, Nina Alexander, Jochen Bauer, Francesco Benedetti, Tiana Borgers, Beatrice Bravi, Irene Bollettini, Erick J. Canales-Rodriguez, Dara M. Cannon, Udo Dannlowski, Annabella Di Giorgio, Kira Flinkenflügel, Paola Fuentes-Claramonte, Lisa Furlong, Ian H. Gotlib, Melissa Green, Dominik Grotegerd, Tim Hahn Verified, Tomas Hajek, Diego Hidalgo-Mazzei, Fleur M Howells, Hamidreza Jamalabadi, Andreas Jansen, James A. Karantonis, Andriana Karuk, Tilo Kircher, Elisabeth Leehr, Yanghee Im, Sean R. McWhinney, Susanne Meinert, Igor Nenadic, Andrea Pfennig, Sara Poletti, Edith Pomarol-Clotet, Yann Quidé, Susan L Rossell, Matthew D. Sacchet, Raymond Salvador, Fabio Sambataro, Salvador Sarró, Freda Scheffler, Kang Hee Sim, Dan Stein, Frederike Stein, Benjamin Straube, Henk S. Temmingh, Florian Thomas-Odenthal, Sophia I. Thomopoulos, Tamsyn Van Rheenen, Enric Vilajosana, Ling-Li Zeng, Ole A. Andreassen, Eduard Vieta, Paul Thompson, Colm McDonald, Joaquim Radua, Bartholomeus C. M. Haarman, Melody J. Y. Kang, Elisa MT Melloni, Lea Teutenberg, Christopher R. K. Ching
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Nature
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Structural brain differences associated with panic disorder: an ENIGMA-Anxiety Working Group mega-analysis of 4924 individuals worldwide - Molecular Psychiatry
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Abstract Neuroanatomical findings on panic disorder (PD) are typically difficult to replicate, with inconsistent effects. These concerns prompted a paradigm shift towards large-scale collaborations, focused on harmonized data extraction and processing for robust examination of PD brain correlates.
By Willem B. Bruin, Janna Marie Bas-Hoogendam, Nynke A. Groenewold, Kevin Hilbert, André Zugman, Francesco Benedetti, Joscha Böhnlein, Paolo Brambilla Verified, Randy L. Buckner, Robin Bülow, Monica E. Calkins, Natalia Chechko, Udo Dannlowski, Katharina Domschke, Thomas Dresler, Gregory A. Fonzo, Andreas J. Forstner, Ruben C. Gur, Catherine J Harmer, David Hofmann, Max A. Laansma, Till Langhammer, Sang-Hyuk Lee, Elisabeth Leehr, Eleonora Maggioni, Susanne Meinert, Hannah Meinert, Jared Nielsen, Spiro Pantazatos, Martin P. Paulus Verified, Brenda W.J.H. Penninx, Sara Poletti, Andrea Reinecke, Theodore D. Satterthwaite, Lianne Schmaal, Jair C. Soares, Nili Solomonov, Murray B. Stein, Benjamin Straube, Jordan W. Smoller, Ardesheer Talati, Sophia I. Thomopoulos, Katharina Wittfeld, Mon-Ju Wu, Yunbo Yang, Ulrike Lueken, Dan Stein
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Nature
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Network-based analysis of differential white matter connectivity in major depressive disorder with and without comorbid anxiety - Neuropsychopharmacology
Abstract Current psychiatric neuroimaging supports the view that major depressive disorder (MDD) is a dysconnection syndrome, characterized by structural brain dysconnectivity. Recent studies investigating this question, however, did not evaluate the involvement of comorbid disorders, of which anxiety disorders (ANX) are particularly prevalent. Here, we investigated the structural connectivity alterations observed in MDD with and without comorbid ANX.
Altered neural processing in middle frontal gyrus and cerebellum during temporal recalibration of action-outcome predictions in schizophrenia spectrum disorders | Schizophrenia
Abstract A key function of the perceptual system is to predict the (multi)sensory outcomes of actions and recalibrate these predictions in response to changing conditions. In schizophrenia spectrum disorders (SSD), impairments in this ability have been linked to difficulties in self-other distinction.
Linking speech patterns to brain structure in affective and psychotic disorders: an integrative natural language processing approach - Molecular Psychiatry
Abstract Language disturbances are central features of serious mental illnesses, yet traditional clinical assessments often rely on subjective evaluation that may overlook subtle speech anomalies.
Regional brain morphology and current antidepressant use: findings from 32 international cohorts from the ENIGMA major depressive disorder working group | Molecular Psychiatry
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Abstract The understanding of how antidepressant (AD) use is associated with brain structure in individuals with major depressive disorder (MDD) remains incomplete. We aimed to examine the association between AD medication use and brain morphology in relation to age and sex by pooling structural neuroimaging and clinical data from 32 cohorts within the ENIGMA-MDD working group.
By Yara J. Toenders, Zeynep Başgöze, Katharina Brosch, Robin Bülow, Geraldo Filho Busatto, Liliana Capitão, Baptiste Couvy-Duchesne, Kathryn Cullen, Christopher G Davey, Ulrika Evermann, Paola Fuentes-Claramonte, Beata Godlewska, Ian H. Gotlib, Roberto Goya-Maldonado, Nynke A. Groenewold, Dominik Grotegerd, Tim Hahn Verified, Hamidreza Jamalabadi, Alec J. Jamieson, Tilo Kircher, Bonnie Klimes-Dougan, Bernd Kramer Verified, Axel Krug, Elisabeth Leehr, Katie McMahon, Sarah E. Medland, Susanne Meinert, Nils Opel, Maria J Portella, Elena Rodríguez-Cano, Philipp Sämann, Anouk Schrantee, Jair C. Soares, Dan Stein, Frederike Stein, Benjamin Straube, Sophia I. Thomopoulos, Marie-José van Tol, Martin Walter, Sarah Whittle, Katharina Wittfeld, Adrian Wroblewski, Mon-Ju Wu, Lianne Schmaal, Hotaka Shinzato, Aslihan Uyar
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Nature
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Transdiagnostic alterations in white matter microstructure associated with suicidal thoughts and behaviours in the ENIGMA Suicidal Thoughts and Behaviours consortium | Translational Psychiatry
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Abstract Previous studies have suggested that alterations in white matter (WM) microstructure are implicated in suicidal thoughts and behaviours (STBs). However, findings of diffusion tensor imaging (DTI) studies have been inconsistent.
By Lejla Colic, Zuriel Ceja, Maria R. Dauvermann, Luca Villa, Yara J. Toenders, Martin Alda, Rosa Ayesa-Arriola, Elizabeth Ballard, Nerisa Banaj, Zeynep Başgöze, Jochen Bauer, Francesco Benedetti, Bianca Besteher, Katharina Brosch, Simon Cervenka, Romain Colle, Philippe Courtet, Kathryn Cullen, Udo Dannlowski, Jennifer Evans, Negar Fani, Kira Flinkenflügel, Naomi Friedman, Ian H. Gotlib, Nynke A. Groenewold, Tomas Hajek, Alexander S. Hatoum, Ian B Hickie, Yoshiyuki Hirano, Andrea Jackowski, Fabrice Jollant, Tilo Kircher, Anna D. Kraus, Axel Krug, Emmanuelle Le Bars, Elisabeth Leehr, Ivan Maximov, Andrew McIntosh, Andrew Mcintosh, Susanne Meinert, Philip Mitchell, Igor Nenadic, Stener Nerland, Emilie Olié, Pedro M. Pan, Fabrizio Piras, Federica Piras, Sara Poletti, Anca-Larisa Sandu, Carl M. Sellgren, Eiji Shimizu, Harry R. Smolker, Jair C. Soares, Frederike Stein, Dan Stein, Benjamin Straube, Florian Thomas-Odenthal, Gerd Wagner, Martin Walter, Heather C. Whalley, Mon-Ju Wu, André Zugman, Kees van Heeringen, Hilary P. Blumberg, Miguel E. Rentería, Behaviours Consortium, Yuki Ikemizu, Yuko Isobe
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Nature
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Gray matter correlates of childhood maltreatment lack replicability in a multi-cohort brain-wide association study - Nature Communications
Abstract Childhood maltreatment effects on cerebral gray matter have been frequently discussed as a neurobiological pathway for depression. However, localizations are highly heterogeneous, and recent reports have questioned the replicability of mental health neuroimaging findings. Here, we investigate the replicability of gray matter correlates of maltreatment, measured retrospectively via the Childhood Trauma Questionnaire, across three large adult cohorts (total N = 3225).
Differential Effects of Self‐Initiated, Externally Triggered, and Passive Movements on Action‐Outcome Processing: Insights From Sensory and Motor‐Preparatory Event Related Potentials
ANOVA analysis of variance BF Bayes factor ERP event-related potential(s) IQR interquartile range LRP lateralized readiness potential RP readiness potential TMS transcranial magnetic stimulation VEP visual evoked potential 1 Introduction In order to successfully interact with the environment, humans must be able to produce different types of movement, both to act on our internal intentions, goals, and desires (self-initiated movements) and in response to events that happen around us...
Association between polygenic risk for Major Depression and brain structure in a mega-analysis of 50,975 participants across 11 studies - Molecular Psychiatry
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Abstract Major Depression (MD) is a prevalent, disabling and life-limiting condition. The neurobiological associations of genetic risk for MD remain under-explored in large samples, with no comprehensive mega-analysis conducted to date. Our study analysed data from 11 separate studies, encompassing 50,975 participants from the ENIGMA Major Depressive Disorder Working Group.
By Xueyi Shen, Yara J. Toenders, Antoine Weihs, Katharina Brosch, Andreas J. Forstner, Tim Hahn Verified, Hamidreza Jamalabadi, Susanne Meinert, Yuri Milaneschi, Philipp Sämann, Aleks Stolicyn, Mark Adams, Florian Thomas-Odenthal, Katharina Wittfeld, Marisol Herrera-Rivero, Nynke A. Groenewold, Udo Dannlowski, Tilo Kircher, Igor Nenadic, Benjamin Straube, Dan Stein, Sarah E. Medland, Axel Krug, Katie McMahon, Greig de Zubicaray, Lianne Schmaal, Andrew McIntosh, Andrew Mcintosh, Heather C. Whalley
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Nature
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Temporal characteristics of hemodynamic responses during active and passive hand movements in schizophrenia spectrum disorder - Schizophrenia
Abstract In healthy individuals, active hand-movements typically elicit earlier neural processing than passive one, reflected by more positive contrast estimates of the first-order temporal derivative (TD) of hemodynamic response function (HRF) in functional MRI (fMRI) analyses. This temporal advantage might be due to prior movement-awareness and predictive mechanisms that support self-other distinction.
Epigenetic markers of disease risk and psychotherapy response in anxiety disorders – a longitudinal analysis of the DNA methylome - Molecular Psychiatry
Abstract Epigenetic mechanisms such as DNA methylation are hypothesized to play a pivotal role in the pathogenesis of anxiety disorders and to predict as well as relate to treatment response.
Choice- and trial-history effects on causality perception in Schizophrenia Spectrum Disorder - Schizophrenia
Abstract Perceiving causality is a low-level, immediate cognitive process based on temporal and spatial cues relating to sensory events and could be viewed as a perceptual judgement. Perceptual judgements in general are affected by a choice- and trial history bias, however, it is not yet fully understood how such a bias integrates into the perception of causality.
Altered Neural Processing in Middle Frontal Gyrus and Cerebellum During Temporal Recalibration of Action-Outcome Predictions in Schizophrenia Spectrum Disorders
Abstract A key function of the perceptual system is to predict the (multi)sensory outcomes of actions and recalibrate these predictions in response to changing conditions. In schizophrenia spectrum disorders (SSD), impairments in this ability have been linked to difficulties in self-other distinction.
Aberrant preparation of hand movement in schizophrenia spectrum disorder: An fMRI study
Abstract Schizophrenia spectrum disorder (SSD) is linked to impaired self-other distinction and action feedback monitoring, largely stemming from sensory-motor predictive mechanisms. However, the neural correlates of these predictive processes during movement preparation are unknown. Here, we investigated whether patients with SSD exhibit aberrant sensory-motor predictive processes reflected in neural activation patterns prior to hand movement onset.
Brain structural correlates of an impending initial major depressive episode - Neuropsychopharmacology
Abstract Neuroimaging research has yet to elucidate whether reported gray matter volume (GMV) alterations in major depressive disorder (MDD) exist already before the onset of the first episode. Recruitment of presently healthy individuals with a subsequent transition to MDD (converters) is extremely challenging but crucial to gain insights into neurobiological vulnerability.
Voluntary action sharpens sensory prediction and facilitates neural processing of contingent sensory stimuli
Abstract Self- and externally generated sensations differ in sensory responses and motor preparation. However, mechanistic evidence linking the two is scarce. Here, participants made active (self-initiated) or passive (finger moved by electromagnet) movements that triggered a bimodal auditory/visual stimulus. These were followed, in a block-wise manner, by a unimodal auditory/visual comparison stimulus, and participants judged which stimulus was brighter or louder.
White matter microstructure in obesity and bipolar disorders: an ENIGMA bipolar disorder working group study in 2186 individuals - Molecular Psychiatry
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Abstract Although specific risk factors for brain alterations in bipolar disorders (BD) are currently unknown, obesity impacts the brain and is highly prevalent in BD. Gray matter correlates of obesity in BD have been well documented, but we know much less about brain white matter abnormalities in people who have both obesity and BD.
By Christoph Abe, Francesco Benedetti, Erlend Bøen, Katharina Brosch, Erick J. Canales-Rodriguez, Torbjørn Elvsåshagen, Kira Flinkenflügel, Lydia Fortea, Benjamin I. Goldstein, Dominik Grotegerd, Fleur M Howells, Kody G. Kennedy, Anna D. Kraus, Mikael Landén, Bradley J. MacIntosh, Colm McDonald, Andrew McIntosh, Andrew Mcintosh, Susanne Meinert, Philip Mitchell, Igor Nenadic, Mary Phillips, Arnaud Pouchon, Joaquim Radua, Jair C. Soares, Benjamin Straube, Chao Suo, Florian Thomas-Odenthal, Amelia Versace, Eduard Vieta, Wei Wen, Heather C. Whalley, Mon-Ju Wu, Ole A. Andreassen, Tomas Hajek, Carlotta Barkhau, Anna Luisa Klahn, Hannah Meinert, Frederike Stein, Enric Vilajosana
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Nature
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Resting-state functional connectivity in anxiety disorders: a multicenter fMRI study - Molecular Psychiatry
Abstract Anxiety disorders (AD) are associated with altered connectivity in large-scale intrinsic brain networks. It remains uncertain how much these signatures overlap across different phenotypes due to a lack of well-powered cross-disorder comparisons. We used resting-state functional magnetic resonance imaging (rsfMRI) to investigate differences in functional connectivity (FC) in a cross-disorder sample of AD patients and healthy controls (HC).
The interplay between polygenic score for tumor necrosis factor-α, brain structural connectivity, and processing speed in major depression - Molecular Psychiatry
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Abstract Reduced processing speed is a core deficit in major depressive disorder (MDD) and has been linked to altered structural brain network connectivity. Ample evidence highlights the involvement of genetic-immunological processes in MDD and specific depressive symptoms. Here, we extended these findings by examining associations between polygenic scores for tumor necrosis factor-α blood levels (TNF-α PGS), structural brain connectivity, and processing speed in a large sample of MDD patients.
By Susanne Meinert, Alexandra Winter, Janik Goltermann, Katharina Brosch, Florian Thomas-Odenthal, Adrian Wroblewski, Friederike David, Eva C. Beins, Dominik Grotegerd, Tim Hahn Verified, Elisabeth Leehr, Jochen Bauer, Andreas J. Forstner, Markus M Nöthen, Hamidreza Jamalabadi, Benjamin Straube, Stephanie Witt, Marcella Rietschel
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Nature
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Facilitation of sensorimotor temporal recalibration mechanisms by cerebellar tDCS in patients with schizophrenia spectrum disorders and healthy individuals | Scientific Reports
Abstract Core symptoms in patients with schizophrenia spectrum disorders (SSD), like hallucinations or ego-disturbances, have been associated with a failure of internal forward models to predict the sensory outcomes of self-generated actions. Importantly, forward model predictions must also be able to flexibly recalibrate to changing environmental conditions, for example to account for additional delays between action and outcome.
The neural signature of psychomotor disturbance in depression - Molecular Psychiatry
Abstract Up to 70% of patients with major depressive disorder present with psychomotor disturbance (PmD), but at the present time understanding of its pathophysiology is limited. In this study, we capitalized on a large sample of patients to examine the neural correlates of PmD in depression. This study included 820 healthy participants and 699 patients with remitted (n = 402) or current (n = 297) depression. Patients were further categorized as having psychomotor retardation, agitation, or no PmD.
Pre‐movement event‐related potentials and multivariate pattern of EEG encode action outcome prediction
1 INTRODUCTION The brain is constantly anticipating and preparing for future events. Voluntary actions are preceded by a planning period in which aspects of the movement, such as its goal, trajectory and timing are prepared (Haggard, 2008).
Facilitation of sensorimotor temporal recalibration mechanisms by cerebellar tDCS in patients with schizophrenia spectrum disorder and healthy subjects
Abstract Core symptoms in patients with schizophrenia spectrum disorder (SSD), such as hallucinations or ego-disturbances, have been associated with a failure of the forward model to adequately predict the sensory outcomes of self-generated actions. Importantly, depending on the requirements of the environment, forward model predictions must also be able to recalibrate flexibly, for example to account for additional delays between action and outcome.
Altered brain dynamic in major depressive disorder: state and trait features - Translational Psychiatry
Abstract Temporal neural synchrony disruption can be linked to a variety of symptoms of major depressive disorder (MDD), including mood rigidity and the inability to break the cycle of negative emotion or attention biases. This might imply that altered dynamic neural synchrony may play a role in the persistence and exacerbation of MDD symptoms.
Using virtual reality to assess gesture performance deficits in schizophrenia patients
Anastasia Pavlidou1*, Geoffrey Gorisse2, Domna Banakou3 and Sebastian Walther1 1University of Bern, University Hospital of Psychiatry and Psychotherapy, Translation Research Centre, Bern, Switzerland 2LAMPA, Arts et Métiers Institute of Technology, Changé, France 3Arts and Humanities Division, New York University Abu Dhabi, Abu Dhabi, United Arab Emirates Gesture performance deficits are prevalent in schizophrenia patients and are strongly associated with poor social communication skills and...
Behavioural and functional evidence revealing the role of RBFOX1 variation in multiple psychiatric disorders and traits - Molecular Psychiatry
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Abstract Common variation in the gene encoding the neuron-specific RNA splicing factor RNA Binding Fox-1 Homolog 1 (RBFOX1) has been identified as a risk factor for several psychiatric conditions, and rare genetic variants have been found causal for autism spectrum disorder (ASD). Here, we explored the genetic landscape of RBFOX1 more deeply, integrating evidence from existing and new human studies as well as studies in Rbfox1 knockout mice.
By Aet O’Leary, Noèlia Fernàndez-Castillo, Florian Freudenberg, Judit Cabana-Domínguez, Emanuel Schwarz, Marcella Rietschel, Heike Tost, Andreas Meyer-Lindenberg, Nina Roth Mota, Barbara Franke, Andreas Heinz, Nina Romanczuk-Seiferth, Henrik Walter, Heike Weber, Georg W. Alpers, Stephanie Witt, Jan Richter, Benjamin Straube, Bru Cormand, Andreas Reif, Anna Y. Yotova, Alexander L. Gerlach
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Nature
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The Brain Is Adaptive Not Triune: How the Brain Responds to Threat, Challenge, and Change
“We do not live to think, but, on the contrary, we think in order that we may succeed in thriving.” —Jose Ortega y Gasset The Triune Brain: an Outdated, Inaccurate Model Theory impacts how research is conducted. An influential theory used to conceptualize brain function and drive research has been the triune brain theory (1–4).
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