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Benoit Ducourneau

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Articles by Benoit Ducourneau

Comprehensive mutational profiling and clinical outcome of adult acute myeloid leukemia patients with NUP98 rearrangement

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By Arnaud Pagès, Emmanuel Raffoux, Céline Berthon, Laurène Fenwarth, Cécile Pautas, Thomas Cluzeau, Delphine Lebon Verified, Madalina Uzunov, Patricio Javier Pereyra, Maël Heiblig, Jean-Valère Malfuson, Laure Farnault, Pierre-Yves Dumas, Sarah Bertoli, Sylvain Chantepie, Nathalie Auger, Audrey Bidet, Augustin Boudry, Isabelle Luquet, Romain Loyaux, Emmanuelle Clappier, Mathilde Hunault, Stephane de Botton, Arnaud Pigneux, Dominique Penther, Eric Delabesse, Raphael Itzykson, Claude Preudhomme, Hervé Dombret, Christian Récher, Nicolas Duployez, Jean-Baptiste Micol, Benoit Ducourneau, Stéphanie Struski, Matthieu Decamp, Vincent Marmouset, Julia Hieulle, Marie-Joelle Mozziconacci, Laureen Chat, Lina El-Mur, Claude Gardin
| Nature Verified
Abstract We report a large cohort of 95 adult patients with acute myeloid leukemia (AML) harboring NUP98 rearrangements (NUP98r). Patient characteristics included a young age (median 50 years [IQR 38-64]), 20% of therapy-related AML, a high WBC count (median 52×109/L), normal karyotype in 32%, FLT3-ITD in 48% and WT1 mutations in 34%. NUP98::NSD1 fusion was the most common (54%), and these patients were significantly younger (41 y vs. 61 y), had more de novo AML (94% vs.
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